English
Ibrutinib Deacryloylpiperidine CAS 330786-24-8 Purity >99.0% (HPLC) Featured Image
  • Ibrutinib Deacryloylpiperidine CAS 330786-24-8 Purity >99.0% (HPLC)

Ibrutinib Deacryloylpiperidine CAS 330786-24-8 Purity >99.0% (HPLC)

Short Description:

Chemical Name: Ibrutinib Deacryloylpiperidine

CAS: 330786-24-8

Purity: >99.0% (HPLC)

Appearance: Off-White to Khaki Powder 

Intermediate of Ibrutinib (CAS: 936563-96-1) 

Contact: Dr. Alvin Huang 

Mobile/Wechat/WhatsApp: +86-15026746401    

E-Mail: alvin@ruifuchem.com


Product Detail

Related Products

Product Tags

Intermediates of Ibrutinib:

Ibrutinib CAS 936563-96-1                           
3-Hydroxypiperidine CAS 6859-99-0 
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid  CAS 2215-77-2
4-Phenoxyphenylboronic Acid CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine  CAS 151266-23-8 
Ibrutinib Deacryloylpiperidine CAS 330786-24-8 
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Chemical Properties:

Chemical Name 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms Ibrutinib intermeidate N-2; Ibrutinib Deacryloylpiperidine; Ibrutinib Impurity 8; 5-(4-Phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine; IBT4A; Ibrutinib N-Despiperidinyl Impurity
CAS Number 330786-24-8
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C17H13N5O
Molecular Weight 303.32
Melting Point >262℃(dec.)
Density 1.380±0.06 g/cm3
Hazard Class 6.1; Poison
Packing Group III
COA & MSDS Available
Origin Shanghai, China
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance Off-White to Khaki Powder 
Identification HNMR, LC-MS
Purity / Analysis Method >99.0% (HPLC)
Loss on Drying <1.00%
Single Max. Impurity <1.00%
Total Impurities <1.00%
Heavy Metals (as Pb) <20ppm
Test Standard Enterprise Standard
Usage Intermediate of Ibrutinib (CAS: 936563-96-1)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture.

Advantages:

1

FAQ:

www.ruifuchem.com

330786-24-8 - Application:

3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS: 330786-24-8) is a useful synthetic intermediate in the synthesis of Ibrutinib (CAS: 936563-96-1). Ibrutinib is a kind of Bruton tyrosine kinase (BTK) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL). MCL and CLL are belonged to the B-cell non-Hodgkin's lymphoma, which is difficult to cure and easy to recurrent. Common chemical immunotherapy does not have the targeting, often occurs 3 or 4 adverse reactions. Ibrutinib and B lymphocytes could target with BTK which is necessary for formation, differentiation, and transmission of information, inhibit BTK activity irreversibly, and inhibit tumor cell proliferation and survival effectively. Ibrutinib could be rapidly absorbed after oral administration, during 1~2h reach maximum blood concentration, adverse reactions belong to one or two, therefore, Ibrutinib will become a new choice of treatment of CLL and MCL.

    • Write your message here and send it to us